Technology Overview
Antimicrobial Effects
Antimicrobial effects of noble metals
For centuries the antimicrobial effects of noble metals has been known. Gold and silver ions have a well recognized antimicrobial effect against many types of microorganisms1,2.
Due to the colloidal nature of the metals, which provides an extensive surface area for a given volume, very small quantities of the metals are highly effective. This means that no antiseptics or other compounds are needed to boost the effect of the Bactiguard® coating.
The antimicrobial reduction has been proven for clinically relevant strains of both Gram-positive and Gram-negative bacteria as well as for fungi.
In vitro test based on ASTM E2149-01 (Dynamic shake flask test); Test material was suspended in artificial urine containing a known number of micro-organisms (clinical isolates) and agitated for 24 h. The Bactiguard® coated sample shows substantial bacterial reduction. Data on file.
Antimicrobial fine-tuning
By steering the coating conditions during the application of the Bactiguard® coating, the noble metal release from the coated surface can be modified. The release profile can also be adjusted in order to get instant kill of microorganisms if desired and suitable for the application.
In vitro test based on ASTM E2149-01 (Dynamic shake flask test); Test material was suspended in artificial urine containing a known number of micro-organisms (clinical isolates) and agitated for 1 and 5 min. The samples were removed from the broth where after the number of adhered bacteria was counted. The Bactiguard® coated sample shows substantial bacterial reduction. Data on file.
References
1 Saygun O. Et al., Gold and Gold-Palladium Coated Polypropylene Grafts in a S. epidermidis Wound Infection Model. J Surg Research. 2006; 131:73-79
2 Guggenbichler, J. et al., A new technology of microdispersed silver in polyurethane induces antimicrobial activity in central venous catheters. Infection, 27 Suppl. 1 p.16-23